European Journal of Molecular & Clinical Medicine

Abstract

Background and Objectives: Although not as glamorous as its surgical counterparts, the management of allergic rhinitis constitutes a large proportion of the day-to-day practice of the general otolaryngologists. In addition to its primary effect, inhalant allergy of the upper respiratory tract might affect the development and clinical course of other disease states such as sinusitis, otitis media, and asthma accounting upto half the patients encountered in an otolaryngological practice. Diethylcarbamazine an antifilarial drug used in the treatment of tropical pulmonary eosinophilia was used in this study to know its role in allergic rhinitis.
Method: A Descriptive study was conducted for one year at Department of DMCH Darbhanga. Selected Patients were administered Tab Diethylcarbamazine 5mg/kg body wt BD for 21 days and their effect on symptom control, blood eosinophilia and nasal   eosinophilia wasstudied. Results: About 100 patients were recruited. 78 patients had eosinophilia either in blood, nasal smear orboth which accounted to significant amount. After treatment with Diethylcarbamazine blood Eosinophilia decreased significantly in both blood and nasal tissue and blood eosinophilia only group. Nasal Eosinophilia decreased significantly in both blood and nasal tissue and nasal tissue only group. Symptoms of sneezing, rhinorrhea, nasal obstruction, nasal pruritis, eye watering and eye itching improved significantly in all 3 groups after treatment. Pharyngeal itching improved only in blood & nasal eosinophilia and blood eosinophilia group. No improvement in Anosmia in all 3 groups.
Conclusion: Eosinophilia was associated in significant number of population and Diethylcarbamazine is useful in reducing the symptom scores in patients of allergic rhinitis with eosinophilia. It also reduces the eosinophil scores in both blood and nasal tissue. Diethylcarbamazine can be used in the treatment of allergic rhinitis with eosinophilia as an adjunctive drug.