European Journal of Molecular & Clinical Medicine

Abstract

Objective: To study the Epidemiological & Clinicopathological characteristics Of Triple Negative Breast Cancer.
Methods: This descriptive cross-sectional study was conducted at a tertiary health centre over the period of 2 years from 2020-2022.The study sample included 100 patents of Biopsy and Immunohistochemistry proven Triple Negative Breast Cancer (TNBC). Age at diagnosis, race, histological grade, tumor size, nodal status, distant metastases, postoperative TNM staging, molecular subtypes, surgical performance, receipt of radiation, and chemotherapeutic administration were among the clinicopathological parameters included in analyses.
Results: Mean age of the 100 study sample was 54.78 years (standard deviation – 5.42 years), with the highest at 66 years and the lowest at 44 years. 44% of TNBC subjects were having stage III disease followed by 32% with stage I &24% with stage IV disease. 24% of TNBC subjects were having metastasis lesions in other parts of the body while the remaining 76% were without metastasis. 45% of TNBC subjects were having stage III disease followed by 32% with stage I & 23%withstageIV disease according to pathological staging. 23% of TNBC subjects were having recurrence within two years after treatment while the remaining 77% were completely cured.
Conclusion: Triple-negative breast cancer is a distinct subtype of the disease that is characterized by a distinct molecular profile, an aggressive pattern of activity, a relative dearth of effective treatments, and a dismal outlook. This subtype carries an adverse prognosis which is even more exemplified in developing countries like India where the relatively lower socio-economic status and lack of awareness about the condition as well as lack of availability of more targeted therapies further add to the morbidity & mortality already associated with the illness. In order to combat this one-of-a-kind and aggressive disease and tailor our approach we need to conduct more extensive research so as to be able to provide the best standard of care to these patients