Significance of positive malignant cells in peritoneal washings and it’s clinicopathological correlation with stage of disease in patients with gastrointestinal malignancy
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 1, Pages 79-83
Abstract
Background: Gynecological malignancies account for three fourth of the female patients who present with malignant ascites. Similarly in males half of the patients with malignant cells in their peritoneal washings have malignancy involving GI tract. This study was conducted to assess free malignant cells in peritoneal cavity with varied clinicopathological profile of patients with gastrointestinal malignancies and its correlation with stage of disease.Materials and Methods: Patients with Gastrointestinal malignancy presenting to surgical OPD during study year were assessed for clinic- pathological stage and malignant cytology. Correlation between presence of positive malignant cytology and clinicopathological stage was assessed.
Results: Out of total 34 patients with malignancies involving colorectal, gastric, esophageal and pancreas, 9 had been found to be having free malignant cells in peritoneal cavity. Advanced stage of the disease with worse clinic-pathological profile had more propensity of free malignant cells in peritoneal cavity
Conclusion: Significant correlation was found between clinicopathological stage and presence of positive malignant cytology. However, we failed to demonstrate any correlation between degree of differentiation of tumor and positive malignant cells in peritoneal cavity
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