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Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom

    Authors

    • Gulyamova T.G. 1
    • Nasmetova S.M. 1
    • Ruzieva D.M. 1
    • Mukhammedov I.I, 1
    • Kadyrova G.Kh. 2
    • Karimova F. A. 1

    1 Institute of Microbiology, Academy of Sciences Republic of Uzbekistan, 100128, Uzbekistan, Tashkent, А. Кadyry st.7b.

    2 Institute of Microbiology, Academy of Sciences Republic of Uzbekistan, 100128, Uzbekistan, Tashkent, А. Кadyry st.7b

,

Document Type : Research Article

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Abstract

The present work was aimed to identify phytochemicals in methanol extract P. brevicaule alba Thom - CC200, obtained from C. cristata , by qualitative and TLC analysis and evaluation of α-amylase inhibitory activity in vitro. It was determined the presence in the extract of glycosides, terpenoids, and saponins. The partitioning of the extract by TLC showed that inhibition of enzyme activity at 50,3% and 37,6% is associated with two compounds of saponin nature.

Keywords

  • diabetes mellitus
  • Endophytic fungi
  • Celosia cristata
  • methanol
  • α-amylase inhibition
  • Phytochemicals
  • saponin
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 2
November 2020
Page 829-836
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  • Article View: 322
  • PDF Download: 495

APA

T.G., G., S.M., N., D.M., R., I.I,, M., G.Kh., K., & A., K. F. (2020). Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom. European Journal of Molecular & Clinical Medicine, 7(2), 829-836.

MLA

Gulyamova T.G.; Nasmetova S.M.; Ruzieva D.M.; Mukhammedov I.I,; Kadyrova G.Kh.; Karimova F. A.. "Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom". European Journal of Molecular & Clinical Medicine, 7, 2, 2020, 829-836.

HARVARD

T.G., G., S.M., N., D.M., R., I.I,, M., G.Kh., K., A., K. F. (2020). 'Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom', European Journal of Molecular & Clinical Medicine, 7(2), pp. 829-836.

VANCOUVER

T.G., G., S.M., N., D.M., R., I.I,, M., G.Kh., K., A., K. F. Phytochemical analysis of α-amylase- inhibiting secondary metabolites of endophyte Penicillium brevicaule alba Thom. European Journal of Molecular & Clinical Medicine, 2020; 7(2): 829-836.

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