Comparison of amnion membrane and bone graft with bone graft alone in the treatment of periodontal intrabony defects: A case study
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 2344-2352
AbstractBackground: Combination guided tissue regeneration for the treatment of periodontal intrabony defects is an accepted treatment modality for many years and has undergone a number of changes. Human amniotic membrane allografts have been used for a variety of reconstructive surgical procedures since the early 1900s. The purpose of this study was to clinically and radiographically evaluate the efficacy of amniotic membrane as a guided tissue regenerative material in the treatment of human periodontal intrabony defects.
Method: Thirty six intrabony defects in eighteen systemically healthy subjects having moderate to severe chronic periodontitis were randomly assigned to control group (treatment with hydroxyapatite bone graft) and test group(treatment with hydroxyapatite and amnion membrane). The plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession (REC) were recorded at baseline, and were reevaluated at 3 and 6 months. In addition to this, radiographic bone fill was assessed using radiovisiograph. At the test site, hydroxyapatite bone graft and amnion membrane was placed, whereas at the control site, only hydroxyapatite bone graft was placed. Clinical and radiographic evaluations were made at baseline, at 3 and 6 months following surgery.
Results: In the control group, the mean reduction of PPD was 3.11 mm and the mean CAL gain was 3.78 mm. In the test group, the mean PPD reduction was 4.33 mm and mean gain in CAL was 5.55 mm after 6 months which was statistically significant. The mean gain in radiographic defect fill was 53.87% in the test and 50.76% in the control group after 6 months which was statistically significant. A significant decrease in mobility and gingival index was observed. .
Conclusion: Amnion membrane is an effective treatment option for the reconstruction of periodontal intrabony defects as it led to statistically significant improvements in the clinical and radiographic parameters.
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