Assessment of onset and progression of chemoradiotherapy induced oral complications in head and neck cancer patients - An original research
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 8752-8757
Abstract
Aim: Purpose of the present research was to assess onset as well as progression of chemoradiotherapy (CRT) induced oral complications in head and neck cancer patients.Methodology: A prospective study conducted among 40 patients with HNC undergoing CRT. Oral complications onset and grades of severity at different time points on a weekly basis for six weeks were assessed. Weekly pairwise comparisons of oral complications was done using the Friedman one‑way repeated measure analysis of variance (ANOVA). The Chi‑squared test was done in oral candidiasis to determine the significance between groups (P < 0.05)
Results: Among 40 HNC patients who completed CRT and showed oral complications, 27 (67.5%) were males and 13 (32.5%) females, with peak age of 51–60 years (40%). All the oral complications had onset first noticed in the second week of CRT except dysphagia that occurred in the first week. A statistically significant difference in oral complications grading during week 1 to week 6 with P < 0.001 was present. All the patients had oral mucositis (OM), xerostomia, and dysgeusia observed in the fourth week, and dysphagia in fifth week. Severity in grading was noticed in the sixth week for all the complications.
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