Comparison of Haemodynamic Changes of Dexmedetomidine with That of Saline Infusion for Spine Surgery in Prone Position under General Anaesthesia
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 8784-8792
AbstractBackground: In this study, we wanted to compare hemodynamic changes in patients receiving dexmedetomidine with those of patients receiving placebo.
Materials and methods: This was a hospital based randomized prospective comparative study conducted among 60 patients who presented to the Department of General Anaesthesia in Seth G S Medical College, KEM Hospital Mumbai from 2013 to 2014 after obtaining clearance from Institutional Ethics Committee and written informed consent from the study participants.
Results: The mean pre-operative heart rate in Group D was 79.83 ± 8.92 beats per minute (bpm) and in group C it was 76.97 ± 8.97 bpm and the difference was not statistically significant (p = 0.208). Immediately after turning the patient prone, the mean heart rate in group D was 79.83 ± 6.28 bpm and that in group C was 90. 25 ± 12.32 bpm and the difference was not statistically significant (p value = 0 784). The mean heart rate was significantly lower in group D compared to group C during rest of the intra operative period. At the time of reversal, the mean heart rate was 88.73 ± 6.24 bpm and 94.31 ± 6.21 bpm in group D and group C respectively. There is significant difference in the mean heart rate with p value 0.001. The pre-operative mean SBP in group D was 123.33 ± 14.15 and that in group C was 125.94 ± 11.45; the difference was not statistically significant with p value 0.244. In comparison of diastolic blood pressure (DBP) at various intervals between Group D and Group C, all the p values were statistically significant. Whereas the pre-operative mean DBP was 82.10 ± 2.11 mm of Hg and 82.63 ± 3.86 mm of Hg in Group D and Group C respectively. The difference was not statistically significant (p value 0.513). In Comparison of MAP at various intervals between Group D and Group C, all the p values were statistically significant. Whereas the pre-operative mean arterial pressure (MAP) in group D patients was 95.73 ± 2.60 mm of Hg and that in group C patients was 97 50 ± 6.53 mm of Hg there is no significant difference in mean MAP between two groups p value 0.172.
Conclusion: Dexmedetomidine provides good intra-operative hemodynamic stability in spine surgeries. The incidence of bradycardia and hypotension were less with the dexmedetomidine in prone position.
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