Association of high-sensitivity C-reactive protein, Malondialdehyde with glycated hemoglobin in type II diabetes patients
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 8833-8837
AbstractBackground: Diabetes mellitus (DM) has become a major and serious threat to global human health. The present study assessed high-sensitivity C-reactive protein, malondialdehyde and their association with glycated hemoglobin in type II diabetes patients.
Materials & Methods: Group I comprised of 96 type II diabetics and group II had 96 healthy control subjects. HbA1c, serum insulin, hs- CRP, Homeostasis model assessment for insulin resistance, serum creatinine and malondialdehyde (MDA) levels were measured.
Results: Group I had 56 males and 40 females and group II had 48 males and 48 females. HOMA- IR was 4.8 in group I and 1.7 in group II, MDA level in group I was 5.07 µmol/L and in group II was 1.31 µmol/L. Creatinine level was 0.98 mg/L in group I and 0.85 mg/L in group II, cystatin C was 0.85 mg/L in group I and 0.92 mg/L in group II. The mean Hs-CRP (mg/L) level was 4.6 in group I and 1.9 in group II. The difference was significant (P< 0.05).
Conclusion: Type II diabetes mellitus patients had elevated level of malondialdehyde and high-sensitivity C-reactive protein as compared to healthy control subjects
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