Prevalence of non-alcoholic fatty liver disease in hypothyroid patients
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 8838-8842
Abstract
Background: The prevalence of NAFLD in adults has been reported to be as high as 33% making it the most common cause of chronic liver disease. The present study assessed prevalence of non-alcoholic fatty liver disease in hypothyroid patients.Materials & Methods: 82 patients of hypothyroidism of both genders were selected and assessment of hypothyroidism was done with measurement of T3, T4 and TSH. Ultrasonography (USG) of all patients was performed and steatosis was graded as 1 if less than 33% of the hepatocytes were affected, grade 2 when 33 - 66% of the hepatocytes were affected, and grade 3 if more than 66% of the hepatocytes were affected.
Results: Out of 82 patients, males were 50 and females were 32. TSH level <5 mIU/ml was seen in 7, 6-20 mIU/ml in 5, 21-35 mIU/ml in 10, 36-50 mIU/ml in 20, 50-65 mIU/ml in 16 and >65 mIU/ml in 24 patients. The difference was significant (P< 0.05). Fatty liver grade I was seen in 10, II in 18 and III in 6 patients. Serum ferritin level in grade I males was 164.5 and in females was 170.2. In grade II males was 512.4 and in females was 234.6 and in grade III males was seen in 586.2 and in females was 376.4. The difference was significant (P< 0.05).
Conclusion: Serum ferritin levels were found to be increased in patients of fatty liver with hypothyroidism. Serum ferritin could help in predicting the natural history of NAFLD in hypothyroidism patients.
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