Association of serum uric acid with albuminuria and carotid atherosclerosis in type 2 diabetes mellitus patients
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 8903-8907
AbstractBackground: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in patients with type 2 diabetes mellitus. The present study was conducted to assess association of serum uric acid with albuminuria and carotid atherosclerosis in type 2 diabetes mellitus patients.
Materials & Methods: 65 type II diabetes mellitus patients of both genders were included. In all, uric acid (UA) was measured by enzymatic photometric test, urine albumin was measured by immunoturbidimetric assay, urine creatinine was measured using creatinine Jaffe method and albumin creatinine ratio (ACR) was calculated by dividing urine albumin concentration with urine creatinine concentration.
Results: Out of 65 patients, males were 35 and females were 30. The mean uric acid in males was 6.82 mg/dl and in females was 5.16 mg/dl.Albumin showed normoalbuminuria in 30, micromoalbuminuria in 20 and macromoalbuminuria in 15. IMT was between 0.4-0.5 cm in 12, 0.5- 0.6 cm in 14, 0.6-0.7 cm in 20 and 0.7-0.8 cm in 9 subjects. The difference was significant (P< 0.05). UA had positive correlation with logarithm of urine albumin excretion and IMT (P< 0.05).
Conclusion: Asymptomatic hyperuricemia is highly prevalent in type 2 diabetic patients. Serum UA concentration serves as early and independent marker of renal dysfunction in type 2 diabetic patients. Serum UA concentration serves as early marker of carotid atherosclerosis in type 2 diabetic patients.
- Article View: 1
- PDF Download: 11