Assessment of Gonadotrophins among Female Thalassemic Children and Their Correlation with Serum Ferritin
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 8908-8915
AbstractIntroduction: Thalassemia is an assembly of conditions which is caused from an inherited defect in the production of one or more globin chains. Endocrine defects in thalassemia major are most prevalent disturbing problems which need quick controlling and therapy.
Objective: To study the occurrence and pattern of endocrinopathies among thalassemic female children (N=55) within 6 months to 18 years of age attending thalassemia day care centre in Department of Paediatrics GMC, Jammu and to determine the correlation of gonadotrophins with serum ferritin.
Results: All of the patients (100%) had thalassemia major. Hypothyroidism and hyperthyroidism were present in 3.63% and 0.01% patients, respectively. Majority (72.72%) of the patients had lower Vitamin B12 level. Diabetes mellitus was present in only 2 patients. All patients had reduced haemoglobin level. All female patients within the age group 13-18 years had reduced LH level. Increased FSH level was present in one female patient. Serum ferritin levels were found high in all the patients. In females ≤ 10 years, megaloblastic anaemia was seen in 68.57% patients, and hypothyroidism and diabetes mellitus in 1 patient each; whereas in females >10 years, hypogonadism (LH) was noted in all patients followed by megaloblastic anaemia in 80% females, and diabetes mellitus, hypergonadism (FSH), and hypothyroidism in 1 patient each. A positive correlation was found between Serum ferritin and LH/ FSH.
Conclusion: This study shed some light on the endocrinal issues linked with thalassemia and increases the previously prevailing studies about the occurrence of endocrinopathies among thalassaemic patients. Gonadotropins were found to be correlated positively with serum ferritin level among these patients. Early detection and institution of appropriate transfusion and chelation therapy and treatment of complication are the keys to manage this disease.
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