Tryptophan As A Nutraceutical – Clinical And A Critical Review
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 9423-9429
AbstractNutraceutical is a combination of the words "nutrition" and "pharmaceutics." The term refers to substances separated from herbal products, dietary supplements, and processed foods such as cereal grains, beverages, and soups, which are being used both as a nutrient and medicine. Ginseng, Echinacea, glucosamine, green tea, flavonoids, lycopene, lutein, folate, and cod liver oil are some popular nutraceuticals. Most nutraceuticals have diverse therapeutic attributes. Tryptophan (Trp) is an amino acid that is required in the human diet. It is essential for many metabolic functions. Trp levels can be used by clinicians to diagnose different metabolic disorders and the associated symptoms with those ailments. Furthermore, due to the Trp relationship with the biosynthetic pathways of serotonin (5-HT) and melatonin, dosing with this amino acid is being regarded in the treatment of depressive disorders and sleep disturbances. It is also used to treat cognitive disorders, anxiety, and neurodegenerative diseases. Diminished serotonin secretion has been linked to autism spectrum disorder, obesity, anorexia and many other diseases. The literature strongly suggests that Trp plays an important role in the proper functioning of the brain-gut axis. Chicken, turkey, red meat, milk, pork, eggs fish, beans, nuts, seeds, and oatmeal, are all high in tryptophan. Tryptophan has a reference dietary intake (RDI) of 4mg per kilogramme of body weight. As a result, a 70kg person should require nearly 280mg of tryptophan per day. The chemical is available as 500 mg capsule in the market as medicine. The rare side effect of an abnormal concomitant intake of the nutraceutical with certain antipsychotic drugs is serotonin syndrome. The described eosinophilic myalgia syndrome was later found to be not associated with this nutraceutical. The drug has got a few side effects and should be prescribed by either a qualified physician or a specialist in human nutrition.
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