Serum Triglyceride Level and Waist Circumference as Predictor of GDM in Later Pregnancy
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 1, Pages 591-596
AbstractBackground: The most frequently encountered medical disorder in pregnancy is gestational diabetes mellitus (GDM) which is multifactorial and no tool has been successful in predicting GDM in early pregnancy. In the modern era association of GDM with metabolic syndrome is coming to light. The clinical marker of visceral obesity which is now coined as hypertriglyceridemic waist phenotype is abdominal obesity in combination with hypertriglyceridemia. The purpose of this study was to find the association between the hypertriglyceridemic- waist phenotype in early pregnancy and glucose intolerance in later pregnancy. Not many studies have been done to show the association of increased waist circumference and elevated serum triglyceride leading to the development of GDM even though it is well known that the interrelation of these leads to subsequent development of Type 2 Diabetes Mellitus (T2DM).
Objective: To determine the association of elevated serum triglyceride level and waist circumference in early pregnancy with the development of GDM in later pregnancy
Materials and methods: It is an observational study where fasting serum triglyceride and waist circumference is measured in 270 consenting pregnant women between 11-14 weeks and followed up. Performance of 75 gm oral glucose tolerance test (OGTT) was done between 24-28 weeks and results were interpreted.
Results: In early pregnancy, a waist circumference of 96.4cm+/-13.6 and a fasting serum triglyceride level of 147.8mg/dl+/-74.8 are interrelated with the development of GDM in later pregnancy. There is 3 times increased chance of developing GDM with a waist circumference of >80cm and 9 times increased chance of developing GDM with a serum triglyceride level of >150mg/dl
Conclusion: In early pregnancy, the “Hypertriglyceridemic Waist Circumference” is associated with the subsequent development of GDM
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