European Journal of Molecular & Clinical Medicine

Abstract

Nuclear protein in Testis (NUT) Midline carcinoma (NMC) is highly aggressive, lethal, uncommonly encountered variant of squamous cell carcinoma, caused by genetic re-arrangement of NUT gene with a gene from BRD family¹. 143 patients were registered to International NMC Registry between 1990 to 2017².Similarly data of 119 patients from 64 literatures published between 1950 to 2017 were retrieved on PUBMED and Google search³. Diagnosis of NMC has increased annually since 2007^{4, 10} (Figure 1).Median age of onset is 24 years¹with equal incidence in male and female.²Most common site of occurrence is thoracic (54%) followed by Head and Neck. (40%) ² Among Head and Neck NMC sinonasal origin is commonest.^1,2,3,5,6,11.Median Overall Survival quoted by various literatures is about 6.8 months².We report a case of a boy who presented to us with typical features of NMC