European Journal of Molecular & Clinical Medicine

Abstract

AIM:To study the efficacy of steroid nasal spray alone and steroid nasal spray with oral steroids in patients of ethmoidal polyposis with chronic rhinosinusitis.
MATERIALS AND METHODS: All the patients with presentation of chronic sinusitis with ethmoidal polyposis, fitting in the definition of the study and fulfilling the inclusion criteria had a detailed history taking of the concerned complaints. Steroid therapy was given to each patient in the study for 6 weeks. One group of patients were given topical steroid in form of mometasone nasal spray for 6 weeks (Group A) and the other group was given mometasone nasal spray along with 8 mg of methylprednisolone for 15 days in a tapering dose (Group B). Each patient underwent a thorough radiological examination of the nose following steroid therapy.
RESULTS: The symptoms were significantly reduced in both of our research groups, but the most improvement was shown in those who had both systemic and local steroid therapy. The odds of improvement with topical steroid treatment only is 0.1905 times that of the odds of improvement with topical and systemic steroid treatment based on CT PNS in all individuals. The symptom and polyp size reduction rate was significantly greater in Group B individuals than in Group A (p value-0.01209) as evidenced on CT PNS.
CONCLUSION: In conclusion the results of this study indicate that thrice daily administration of 8 mg oral preparation of methylprednisolone for 15 days and topical steroid in the form of nasal spray for 6 weeks is an efficacious treatment for chronic rhinosinusitis with ethmoidal polyposis. It also provides significant relief of symptoms, reduction in polyp size and overall control of mucosal inflammation and tissue remodeling (p value- 0.012)