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Ki-67 Proliferation Index In Carcinoma Breast: Pitfalls In Assessment

    Author

    • Cheena Garg, Amit Kumar, Arjun Agarwal, Nitesh Mohan .

    .

,

Document Type : Research Article

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Abstract

Introduction: Ki-67 proliferation index is used as a prognostic-predictive marker in breast carcinoma and determined using visual hotspots or global counts methods. We studied analytical objectivity and reproducibility using the two methods.
Material and Method: 56 cases of carcinoma breast with Ki-67 (MIB-1antibody) staining on same sections were evaluated by two equally experienced pathologists, blinded to each other using both methods. The values obtained were classified into low, intermediate and high categories and statistical analysis was done using SPSS ver21.0 software.
Result: The mean value of hotspot method was higher whereas global method showed better interobserver reliability.
Conclusion: We recommend global method of Ki-67 evaluation as it has better reproducibility and inter-observer agreement as compared to visual hot spot method. The latter which has a higher mean value may result in change in categorization of Ki-67 index especially at higher end of cut-off in intermediate category, thereby affecting treatment protocols.

Keywords

  • Ki-67 Proliferation Index
  • average method
  • visual hotspot method
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European Journal of Molecular & Clinical Medicine
Volume 9, Issue 8 - Issue Serial Number 8
December 2022
Page 2915-2921
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  • Article View: 33
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APA

., C. G. A. K. A. A. N. M. (2023). Ki-67 Proliferation Index In Carcinoma Breast: Pitfalls In Assessment. European Journal of Molecular & Clinical Medicine, 9(8), 2915-2921.

MLA

Cheena Garg, Amit Kumar, Arjun Agarwal, Nitesh Mohan .. "Ki-67 Proliferation Index In Carcinoma Breast: Pitfalls In Assessment". European Journal of Molecular & Clinical Medicine, 9, 8, 2023, 2915-2921.

HARVARD

., C. G. A. K. A. A. N. M. (2023). 'Ki-67 Proliferation Index In Carcinoma Breast: Pitfalls In Assessment', European Journal of Molecular & Clinical Medicine, 9(8), pp. 2915-2921.

VANCOUVER

., C. G. A. K. A. A. N. M. Ki-67 Proliferation Index In Carcinoma Breast: Pitfalls In Assessment. European Journal of Molecular & Clinical Medicine, 2023; 9(8): 2915-2921.

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