European Journal of Molecular & Clinical Medicine

Abstract

Background: Mupirocin is a powerful topical antibiotic for treating carriers of MRSA. Resistance to this medication has grown as a result of its frequent use in clinical settings and over-the-counter accessibility. Concern is also raised by Staphylococcus aureus having Mupirocin resistance. Materials and Methods:  It is a cross sectional study conducted in in Department of Microbiology during the period of May 2016 to April 2017. 1200 patients were selected in the study. Out of which, 400 patients were inpatients, 400 patients from community and 400 were from health care workers. Results: 64 (16%) were MRSA carriers out of 400 inpatients, 48 (12%) were MRSA carriers out of 400 health care workers and 25 (6.25%) were MRSA carriers out of 400 community samples. 137 (11.4%) were overall MRSA carriers. 33 (51.5%) patients from a total of 64 culture positive MRSA inpatients  were sensitive to mupirocin and 31 (48.5%) were mupirocin resistant. 11 (17.2%) showed low level resistance and 20 (31.3%) showed high level resistance among 31 isolates which were resistant. 21 (43.8%) patients from a total of 48 culture positive MRSA health care workers  were sensitive to mupirocin and 27 (56.2%) were mupirocin resistant. 6 (12.4%) showed low level resistance and 21 (43.8%) showed high level resistance among 27 isolates which were resistant. 11 (44%) patients from a total of 25 culture positive MRSA community samples were sensitive to mupirocin and 14 (56%) were mupirocin resistant. 4 (16) showed low level resistance and 10 (40) showed high level resistance among 14 isolates which were resistant. Five of the individuals who had the 2% Mupirocin treatment test negative for nasal carriage of Staphylococcus aureus in each of the four follow-up swabs. Twelve of the people who used intensified hygiene practises had no nasal carriage of Staphylococcus aureus in any of the four follow-up swabs. Conclusion: Instead of utilising Mupirocin ointment, decolonization with adjusted hygiene behaviours including routine hand washing and nose cleaning produced positive effects.