European Journal of Molecular & Clinical Medicine

Abstract

Inflammatory disease of the temporal bone called cholesteatoma is caused by the growth of keratinizing squamous epithelium, keratin debris and various perimatrix thicknesses, with or without a concomitant inflammatory response. As a result of the release of osteoclasts and mononuclear inflammatory cells, surrounding structures such the scutum, tegmen and ossicular chain deteriorate.
Methods: The current study is set up as an observational study that will be conducted in the ENT and Radiology departments of Kamineni Institute of Medical Sciences, Narketpally, Telangana, India, between November 2021 to October 2022, with the approval of the ethics committee and the patients' written agreement.
Results: In this study, the sensitivity of HRCT staging for middle ear cholesteatoma is 86.6% and the agreement and association with the surgical outcomes are excellent. The underestimation of cholesteatoma at CT may be due to the cholesteatoma sac, associated granulation tissue, mucosal edema and effusion that may be undetected in HRCT images.
Conclusion: In order to reduce comorbidity, the surgeon can choose the optimum type of surgery to undertake with the use of the new non-invasive HRCT staging method proposed in this study for middle ear cholesteatomas.