European Journal of Molecular & Clinical Medicine

Abstract

A rare chronic inflammatory disorder with no known cause, Kimura disease (KD) is typically found in young Asian males. The condition is characterized by frequent enlargement of the salivary glands and a painless subcutaneous swelling in the head and neck region. Elevated immunoglobulin E (IgE) levels and eosinophilia in the blood and tissues are frequently associated. Eosinophilic infiltrates, follicular hyperplasia, and postcapillary venule proliferation are typical histological findings of biopsy specimens taken from subcutaneous swellings or lymph nodes. Even so, the course is typically benignly waxing and waning. A patient who receives an early diagnosis may avoid needless intrusive procedures. In this article, we describe a case of KD in a 40-year-old man who had two surgical procedures for subcutaneous edema in the left submandibular region before being  reassessed and finally diagnosed  as KD  in 2022, based  upon peripheral blood eosinophilia, raised serum IgE levels and histopathological
findings. He subsequently made a good recovery on oral steroids.