Assessment of micro-organism in endotracheal tube aspirate and their sensitivity to drugs with patients on mechanical ventilation
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 7, Pages 9726-9731
Abstract
The likelihood of contracting an infection while in a hospital depends on a number of factors, including the quality of the hospital's infection prevention measures, the health of the patient, and the prevalence of certain pathogens in the surrounding area. The present study was conducted to find micro-organism in endotracheal tube aspirate and their sensitivity to drugs with patients on mechanical ventilation.Materials & Methods: 100 patients between the age of 18 to 65 years on mechanical ventilation admitted to department of Medicine, Gandhi Medical College and associated Hamidia Hospital Bhopal were included. Parameter such as system involved, micro-organism in endotracheal tube aspirate and their antibiotic sensitivity was recorded.
Results: The majority of the patients in our study belong to 51-60 (21%) and 61-70 (19%) years of age group followed by more than 70 years (15%),41-50 years (12%0, 31-40 years (12%), 21-30 years (12%) and less than 20 years (9%) of age. Majority of the patients in our study was male (72%) as compared to female (28%). Majority of the patients had neurological system involvement (41.6%) followed by respiratory (21.8%) and gastrointestinal system (21.8%). There were patients who had been involved renal (14.9%), with diabetes (21.8%) and cardiovascular system (3%) involvement. Most common microorganism isolated from culture was Klebsiella O (7%) and Acinetobacter (7%) followed by Pseudomonas (5%), Citro (2%), Klebsiella P (2%), Staphylococcus species (1%) and MRSA (1%) in our study. In terms of antibiotic sensitivity of ET tube aspiration sample, majority of the patients had bacteriological profile resistant to ampicillin (92.3%), nitrofurantoin (92.3%), cefotaxime (88.55), ceftriaxone (84.6%), cefepime (69.2%), gentamicin(69.2%), imipenem (69.2%), meropenem (69.2%), piperacillin and tazobactum (65.4%), ciprofloxacin (61.5%), amoxiclav (65.4%) and amikacin (42.3%).
Conclusion: Majority of the patients had neurological system involvement. Most common microorganism isolated from culture was Klebsiella O and majority of the patients had bacteriological profile resistant to ampicillin
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