European Journal of Molecular & Clinical Medicine

Abstract

In coronary artery disease (CAD) a mismatch exists between myocardial oxygen consumption and supply. Anesthetic goal targets balance between this supply and demand perioperatively for improved tissue perfusion. Studies show high thoracic epidural anesthesia (HTEA) helps to achieve this goal.
Aims and Objective: To find out the effectiveness of HTEA in achieving improved tissue perfusion as measured by mixed venous oxygen saturation (SvO2) in patients undergoing coronary artery bypass grafting (CABG).
Design of Study: Randomized control study
Material and Method: Prospective randomized control study, where patients undergoing CABG were randomized into 2 groups; Group A: general anesthesia with HTEA and Group B: general anesthesia with conventional opioids. The objectives were to compare SvO2, heart rate (HR), blood pressure [systolic blood pressure
(SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP)], pulmonary artery wedge pressure (PWAP) and blood lactate levels