• Register
  • Login

European Journal of Molecular & Clinical Medicine

  1. Home
  2. A Prospective Analysis of Clinical Characteristics, Treatment and Outcome of Patients with Locally Advanced or Metastatic Gall Bladder Cancer

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

Journal Metrics

News

A Prospective Analysis of Clinical Characteristics, Treatment and Outcome of Patients with Locally Advanced or Metastatic Gall Bladder Cancer

    Author

    • Dr Prashant kumbhaj, Dr Vishesh Gumdal, Dr Vinay Kumar Mahala, Dr Deepak Singla, Dr Dinesh Yadav, Dr Prakash Chitalkar .

    .

,

Document Type : Research Article

  • Article Information
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

Background: Gallbladder cancer (GBC) is a major cause of cancer mortality in parts of the world where it is common including India. Gemcitabine with cisplatin is currently the standard of care for pateints with advanced biliary tract cancers. The aim of the study is to Determine The Clinical Characteristics, Treatment And Outcome of Patients With Locally Advanced Or Metastatic Gall Bladder Cancer.
Materials and Methods: This is a prospective study of metastatic and unresectable gall bladder carcinoma patients presented in Sri Aurobindo Institute of Medical Sciences from Feb 15 to Dec16.Total 30 patients were evaluated with initial clinical characteristic like jaundice, leukemoid reaction, hepaticencephalopathy, Metastatic sites, Ascites, Tumor Markers. Chemotherapy, Gemcitabine 1000mg/m2 D1 and D8 combined with Oxaliplatin 100mg/m2 D1 Every 21 days were given. Interim Response was assessed after 3-4 cycles and after completion of treatment .Patients progressing on initial chemotherapy were offered 2nd line chemotherapy or best supportive care according to performance status.
Results: Median age was 60 years. There were 17(57%) women and 13(43%) men diagnosed with advanced GBC. Out of 30 patients 7(23%) had encephalopathy and 23(76%) had ascites. The median CA19.9 was 23 U/mL, median CEA 3.01 ng/mL, median billirubin 11.72 mg/dl, median leucocyte count 14700, median AFP 2.1ng/ml .Site of metastases was nodal in 17(56%), Liver (10(33.3), peritoneal in 3(10%) and bilateral ovarian in 1(3.3%) patient. Extrabdominal 1(3.3%). Total 30 patients received Gemcitabine with oxaliplatin chemotherapy. The median number of cycles administered was 4 (Range 1-6). 30 Patients were evaluated for response ,out of which 1 (3.3% ) had CR, 9(30%) had PR, 2(6.6%) had SD, and 18 (60%) had progressive disease as their best response with first line chemotherapy. The grade 3 & 4 toxicities reported on treatment included, thrombocytopenia in 4 (13%) patients, neutropenia in 2 (6%),Liver Toxicity occurred in 3 (10%) patients, platinum induced peripheral neuropathy interfering with daily activities was documented in 3 (10%) and diarrhea requiring hospital treatment occurred in 4 (13 %).
Conclusion: This is the prospective study to show tolerance and efficacy of Gem-Ox in patients with advanced GB cancer. The clinical benefit rate is low at 40 % suggesting that the biology of advanced GB cancers patients is likely to be aggressive and needs to be studied in large prospectively designed studies with newer chemotherapy or targeted therapies.

Keywords

  • Complete remission
  • Partial remission
  • Gall bladder cancer
  • Gemcitabine
  • XML
  • PDF 190.99 K
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
    • Article View: 47
    • PDF Download: 91
European Journal of Molecular & Clinical Medicine
Volume 10, Issue 1 - Issue Serial Number 1
January 2023
Page 2561-2568
Files
  • XML
  • PDF 190.99 K
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
Statistics
  • Article View: 47
  • PDF Download: 91

APA

., D. P. K. D. V. G. D. V. K. M. D. D. S. D. D. Y. D. P. C. (2023). A Prospective Analysis of Clinical Characteristics, Treatment and Outcome of Patients with Locally Advanced or Metastatic Gall Bladder Cancer. European Journal of Molecular & Clinical Medicine, 10(1), 2561-2568.

MLA

Dr Prashant kumbhaj, Dr Vishesh Gumdal, Dr Vinay Kumar Mahala, Dr Deepak Singla, Dr Dinesh Yadav, Dr Prakash Chitalkar .. "A Prospective Analysis of Clinical Characteristics, Treatment and Outcome of Patients with Locally Advanced or Metastatic Gall Bladder Cancer". European Journal of Molecular & Clinical Medicine, 10, 1, 2023, 2561-2568.

HARVARD

., D. P. K. D. V. G. D. V. K. M. D. D. S. D. D. Y. D. P. C. (2023). 'A Prospective Analysis of Clinical Characteristics, Treatment and Outcome of Patients with Locally Advanced or Metastatic Gall Bladder Cancer', European Journal of Molecular & Clinical Medicine, 10(1), pp. 2561-2568.

VANCOUVER

., D. P. K. D. V. G. D. V. K. M. D. D. S. D. D. Y. D. P. C. A Prospective Analysis of Clinical Characteristics, Treatment and Outcome of Patients with Locally Advanced or Metastatic Gall Bladder Cancer. European Journal of Molecular & Clinical Medicine, 2023; 10(1): 2561-2568.

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Glossary
  • Sitemap

News

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

© Journal Management System. Powered by ejournalplus