European Journal of Molecular & Clinical Medicine

Abstract

“Acute pancreatitis (AP) is defined as a sudden onset pancreatic inflammatory process” and is associated with complications such as Multi organ dysfunction syndrome leading to increased hospitalizations and mortality rates.
Aim: This study aims at studying the role of CRP done at admission and at 24 hours as a simple and effective prognostic predictor of Severe Acute Pancreatitis and as an alternative to the complex scoring systems available.
Methods: A hospital based observational study was conducted during October 2020 to September 2022 among 50 AP participants aged between 18- 65 years diagnosed using standard criteria. The study will help to translate the significance of CRP done at admission and at 24 hours as a prognostic predictor after comparisons within two clinical grades of AP - Mild Acute pancreatitis-(MAP) and Severe Acute pancreatitis (SAP).
Results: The mean difference of CRP done on admission and at 24hrs between Mild vs Severe Acute Pancreatitis was statistically significant with a P VALUE <0.05. Upon comparing the AUC for both CRP done on admission and CRP at 24 hours, CRP at 24 hours is found to be not of greater significance in predicting the outcomes of disease and is not a better prognostic marker than CRP done on admission.
Conclusion: In our study, both CRP at admission and CRP at 24 hours were statistically significant in predicting the severity of Acute pancreatitis but the CRP levels done at 24 hours were not found to be superior to CRP done on admission to assess disease severity