Study Of The Effects Of Various Insufflating Agents During General Anaesthesia And Correlation Of Acid Base And Gas Blood Changes During Laparoscopy To Determine Ideal Insufflating Agent Amongst CO2, O2 And N2O
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 1689-1696
Abstract
Background: Laparoscopy involves the visualization of abdominal and pelvic organs after creating an artificial pneumoperitoneum. Present study was aimed at to study effects of various insufflating agents during general anaesthesia and correlation of acid base and blood gas changes during laparoscopy to determine ideal insufflating agent amongst CO2, O2 and N2O at a tertiary hospital. Material and Methods: Present study was single-center, comparative study, conducted in female patients from age group of 20-40 years in ASA Class – I/ II undergoing diagnostic laparoscopy and laparoscopic tubal ligation. 105 patients were divided in three groups of 35 patients each as Group- I (oxygen as the insufflating agent), Group II (Nitrous oxide as the insufflating agent) & Group III (carbon dioxide as the insufflating agent).Results: Mean age, body weight & types of procedures were comparable among all groups & no significant statistical difference was noted. The blood gas analysis showed a rise in PaO2 and O2 saturation, due apparent rise mainly to the FiO2. Though the PaO2 is adequate to meet in increased the tissue oxygen demand it is inconsistent with the FiO2 (33%) delivered. The post operative and oxygen saturation came back to their pre-operative values. The PaCO2 was significantly higher intra-operatively in all the three groups, with a numerically high value in Group III. The PECO2 followed the trend of PaCO2 and the fall of pH was consistent with the rise in PaCO2. Though the rise of the PaCO2& fall in pH was statistically significant, they did not reach hazardous level. The Group I had the highest incidence of nausea and vomiting (88.57 %) followed by Group II (14.28 %). Conclusion: Nitrous oxide appears to be the most suitable amongst the three gases; Oxygen, Nitrous oxide and carbon dioxide, with general anaesthesia.- Article View: 3
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