European Journal of Molecular & Clinical Medicine

Abstract

Despite insulin treatment and a meticulously controlled diet, approximately 15% of all patients with diabetes will, at some time, have non-healing wounds and this is the leading cause of lower extremity amputation. Wound healing involve cell adhesion, migration, proliferation, differentiation, and apoptosis. Abnormalities of distinct factors of wound healing like decreased growth factor production, angiogenic response, macrophage function, collagen accumulation, epidermal barrier function, and fibroblast migration and proliferation contribute to defective healing in diabetes. Relative or absolute lack of insulin or its action is a hallmark of diabetes disease and defective insulin action in the skin contributes to defects in wound healing [1].