European Journal of Molecular & Clinical Medicine

Abstract

The corona virus disease which is declared by the WHO as a pandemic and India has emerged as fifth worst hit nation in terms of total number of cases. It has significant impact on hematopoietic system, haemostasis as well as immune system. It would be of utmost importance to explore if the most routinely used tests could serve as an aid in determining patients clinical status or predicting severity of the disease.
A prospective cross-sectional study was conducted on 130 RT –PCR positive patients over a period of 4 months (march -July 2021). The cases were subclassified based on disease severity into mild, moderate, and severe cases. The haematological parameter and infectious biomarkers in these cases were studied.
The median age was 45 years. Haematological parameters like TLC, Neutrophil count, NLR ratio and Inflammatory markers like LDH,CRP,D-Dimer and Ferritin were significantly higher in severe disease (P<0.05) in comparison to moderate and mild cases, while lymphocyte count was lower in severe cases. It showed a strong positive correlation with disease severity.  The diagnostic values were assessed by ROC and AUC. The best cut off value obtained for Total count was16,195, with sensitivity66% and specificity96% .CRP was39.65 , with sensitivity94% and specificity87% .D-dimer was0.555, with sensitivity100%and specificity 100% .Ferritin was481.0 , with sensitivity100% and  86% specificity .