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  2. Volume 10, Issue 1
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Online ISSN: 2515-8260

Volume10, Issue1

Home Dna Testing For Neuropsychiatric Disorders Like Stress, Anxiety, Depression And Personalised Ashwagandha Dosage For Prevention And Cure: A Review Of Recent Development

    Gautam Chikkara, Pallavi Mittal and Surendra K Chikara .

European Journal of Molecular & Clinical Medicine, 2023, Volume 10, Issue 1, Pages 3929-3938

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Abstract

Worldwide 284+ million people suffer from stress, anxiety and depression disorders and modern lifestyle, environments and unhealthy diets are causing an epidemic of stress, anxiety & depression (SAD) disorders. Other risk factors which contribute to SAD disorder are compromised genetics, weak immune system, low response to stress & brain neuroplasticity. Several studies had investigated genes, single nucleotide variation, Indels, large deletions, inversions & triple repeat polymorphism involved in various molecular and biological mechanisms underlying the disease initiation & progression. Recent genome-wide association studies (GWAS) have identified 150+ genes and genetic association of 44 risk variants [1, 2] for detection of SAD disorders. Nowadays At-home DNA tests (direct-to-consumer DNA tests) are gaining popularity for wellness and healthy longevity. These tests predict risk for micronutrient & vitamin deficiency, antioxidant activity, neuro-muscular functionality, risk for SAD disorders, efficacy of pharmacologically active herbal formulations for prevention & cure. On the basis of genetic outcome, medicinal plants/ herbs have been greatly employed to combat and reduce stress, anxiety & depression and thereby enhance general wellbeing in recent years. Ashwagandha (Withania somnifera, fam. Solanaceae) is a most versatile and potential herb of the Indian Ayurvedic system of medicine as a Rasayana. It is also accredited as a ‘royal herb’ having potential therapeutic applications. There are more than 33,787 publications for genetic markers for SAD & due to health awareness Ashwagandha research has gained scientific importance as evidenced by 77 publications documented since 2010 in NCBI PubMed [3]. The present review concludes with a discussion of prospects for clinical translation of genetic findings based on DNA testing, mode of action & personalized dosage of Ashwagandha as potent anti-SAD medicinal supplement
Keywords:
    Home DNA testing stress anxiety depression Ashwagandha
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(2023). Home Dna Testing For Neuropsychiatric Disorders Like Stress, Anxiety, Depression And Personalised Ashwagandha Dosage For Prevention And Cure: A Review Of Recent Development. European Journal of Molecular & Clinical Medicine, 10(1), 3929-3938.
Gautam Chikkara, Pallavi Mittal and Surendra K Chikara .. "Home Dna Testing For Neuropsychiatric Disorders Like Stress, Anxiety, Depression And Personalised Ashwagandha Dosage For Prevention And Cure: A Review Of Recent Development". European Journal of Molecular & Clinical Medicine, 10, 1, 2023, 3929-3938.
(2023). 'Home Dna Testing For Neuropsychiatric Disorders Like Stress, Anxiety, Depression And Personalised Ashwagandha Dosage For Prevention And Cure: A Review Of Recent Development', European Journal of Molecular & Clinical Medicine, 10(1), pp. 3929-3938.
Home Dna Testing For Neuropsychiatric Disorders Like Stress, Anxiety, Depression And Personalised Ashwagandha Dosage For Prevention And Cure: A Review Of Recent Development. European Journal of Molecular & Clinical Medicine, 2023; 10(1): 3929-3938.
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