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  2. A Prospective Randomized Study Comparing Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to Hyperbaric Ropivacaine in Infra Umbilical Surgeries

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A Prospective Randomized Study Comparing Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to Hyperbaric Ropivacaine in Infra Umbilical Surgeries

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    • Sucheta Hans, Sangeeta Singh, Supriya Shree, Nikhil Menia
,

Document Type : Research Article

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Abstract

Spinal anaesthesia is the most preferred technique for infraumbilical surgeries.Hyperbaric Ropivacaine has been shown to produce reliable and predictable anaesthesia for surgery. Fentanyl, a synthetic lipophilic opioid and Dexmedetomidine, a new highly selective α2-agonist, have been used as neuraxial adjuvants in spinal anaesthesia to prolong intraoperative and postoperative analgesia. The present prospective randomized study is undertaken to investigate and compare the clinical effects of 0.75% hyperbaric ropivacaine with additives such as fentanyl and dexmedetomidine on spinal anaesthesia for infraumbilical surgeries.
Aim: To compare the clinical effects of intrathecal 2ml of 0.75% hyperbaric ropivacaine with fentanyl 25μg and dexmedetomidine 10μg as additives in patients undergoing elective infraumbilical surgeries.
Materials & Methods: The study was conducted on 90 patients of both sexes, aged 18-60 years, of class I or II of the American Society of Anesthesiologists classification, who underwent elective infraumbilical surgery. Patients were randomly assigned to three groups (30 patients each): group RC (control group) received 2ml (15mg) of 0.75% hyperbaric ropivacaine plus 0.5ml of normal saline (0.9%) at a total volume of 2.5ml intrathecally, whereas group RF received 2ml (15mg) of 0.75% hyperbaric ropivacaine plus 0.5ml of 25μg fentanyl (50 μg/ml) at a total volume of 2.5ml intrathecally and group RD received 2ml (15mg) of 0.75% hyperbaric ropivacaine plus 0.5ml of 10μg dexmedetomidine (50μg dexmedetomidine diluted in 2.5ml of normal saline) at a total volume of 2.5ml intrathecally. The onset, extent, duration of sensory and motor blockade, time to first rescue analgesia request, hemodynamic parameters, and side effects such as nausea, vomiting, pruritis, respiratory depression and shivering were recorded.

Keywords

  • Spinal anaesthesia
  • Hyperbaric Ropivacaine
  • Bupivacaine
  • fentanyl
  • dexmedetomidine
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European Journal of Molecular & Clinical Medicine
Volume 10, Issue 1 - Issue Serial Number 1
January 2023
Page 4087-4103
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  • Article View: 33
  • PDF Download: 111

APA

Nikhil Menia, S. H. S. S. S. S. (2023). A Prospective Randomized Study Comparing Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to Hyperbaric Ropivacaine in Infra Umbilical Surgeries. European Journal of Molecular & Clinical Medicine, 10(1), 4087-4103.

MLA

Sucheta Hans, Sangeeta Singh, Supriya Shree, Nikhil Menia. "A Prospective Randomized Study Comparing Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to Hyperbaric Ropivacaine in Infra Umbilical Surgeries". European Journal of Molecular & Clinical Medicine, 10, 1, 2023, 4087-4103.

HARVARD

Nikhil Menia, S. H. S. S. S. S. (2023). 'A Prospective Randomized Study Comparing Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to Hyperbaric Ropivacaine in Infra Umbilical Surgeries', European Journal of Molecular & Clinical Medicine, 10(1), pp. 4087-4103.

VANCOUVER

Nikhil Menia, S. H. S. S. S. S. A Prospective Randomized Study Comparing Intrathecal Dexmedetomidine and Fentanyl as Adjuvants to Hyperbaric Ropivacaine in Infra Umbilical Surgeries. European Journal of Molecular & Clinical Medicine, 2023; 10(1): 4087-4103.

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