European Journal of Molecular & Clinical Medicine

Abstract

Background and Objective: Recently, complex and unusual dengue virus infections have become a significant public health concern. Dengue may cause hepatomegaly, increased liver enzymes, and fulminant hepatic failure. To research childhood dengue hepatic dysfunction. To investigate intensity, clinical features, laboratory data, morbidity, and death.
Methods: 110 patients admitted to the Department of Paediatrics, Kamineni Institute of Medical Sciences, Narketpally, Telangana, India, due to a Dengue illness were the subjects of a prospective cohort study from March 2021 to April 2022. Patients who tested positive for the Dengue virus were chosen for further evaluation, including a complete blood count, liver function tests, abdominal ultrasound, PT, APTT, HBsAg, HCV, and Widal testing.
Result: 110 patients with dengue infection were hospitalised; 46 were diagnosed as having probable dengue, 51 as having warning signs, and 13 as having severe dengue. 42% of patients showed signs of hepatomegaly. Comparing the two groups, 88% of patients exhibited warning signals, while 100% had severe dengue. 70% of patients with probable dengue, 94% with warning signs, and 100% with severe dengue experienced thrombocytopenia. In our study, three severe dengue cases passed away. The enzyme levels were extremely high in these two cases