A Clinical Prospective Study to Determine the Effect of Metformin on Clinical Features, Metabolic, Endocrine Profile and Insulin Sensitivity in Polycystic Ovarian Syndrome (PCOS) Patients at Newly Established Tertiary Care Center
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 1855-1861
AbstractBackground: Polycystic ovary syndrome (PCOS) is a heterogenous disorder and current proposed diagnostic criteria include a number of disorders with similar phenotypes but radically different etiologies. Menstrual irregularities are the most common finding among women with PCOS. The aim of this study to determine the effect of metformin on clinical features, metabolic, endocrine profile and insulin sensitivity in polycystic ovarian syndrome (PCOS) patients at newly established tertiary care center.
Materials& Methods: A hospital based prospective study done on 30 obese women with PCOS attending in the department of Obstetrics and Gynaecology at Government Medical College, Pali, Marwar, Rajasthan, India. Thirty females aged 18-35 years having polycystic ovarian syndrome were enrolled and studied for a period of 6 months. The observations were recorded on day 0 and day 180 for various parameters and they were statistically evaluated by using student (paired) t-test for comparison from day0 to day180.
Results: Metformin treated patients showed significant improvement in all parameters i.e. Physiological parameters (Bodyweight, BMI, Systolic blood pressure except diastolic blood pressure), Metabolic parameters (Fasting blood glucose, Fasting serum insulin), Endocrinal parameters (Serum testosterone) indicating that Metformin is of benefit in reducing insulin resistance.
Conclusion: We concluded that Metformin treated patients showed significant improvement in all parameters (except diastolic blood pressure) indicating that Metformin is of benefit in reducing insulin resistance. It seems that Metformin has a direct effect on human ovarian steroidogenesis in addition to reduction of weight and body mass index.
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