European Journal of Molecular & Clinical Medicine

Abstract

Introduction: One of the most serious complications of diabetes is diabetic nephropathy, which is also known to increase the risk of cardiovascular events. Patients with diabetic nephropathy have abnormal lipid levels, which raises their risk of cardiovascular problems. In this study, type 2 diabetes mellitus (T2DM) patients with and without nephropathy had their levels of dyslipidemia compared, and the causes of nephropathy were examined.
Method: Patients with T2DM who had overt nephropathy were included in the study group and those without nephropathy were included in the control group in this retrospective analysis. Age and diabetes duration were matched between the two groups. The case sheets were used to gather information on total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), urea, and creatinine. Equations were used to compute the TG/HDL-C ratio, a proxy for small, dense LDL particles (sdLDL), and the estimated glomerular filtrationrate (eGFR). The variables linked to eGFR were identified using multivariate analysis.
Result: 56.51% of control individuals and 75.28% of nephropathy subjects both had dyslipidemia (P=0.011). In comparison to controls, people with nephropathy had a higher percentage of subjects with atherogenic dyslipidemia (high TG+low HDL-C+sdLDL) at 14.60 than controls did at 14.12. Despite there being no discernible differences in serum creatinine, patients with nephropathy had significantly lower mean eGFR values (P=0.001). Multivariate analysis revealed that TC (P=0.007) and HDL-C (P=0.05) were linked to eGFR among the participants in our study.
Conclusion: According to our findings, dyslipidemia was very common in nephropathy patients. Regular testing for dyslipidemia may help diabetic nephropathy patients reduce their risk of adverse outcomes.