European Journal of Molecular & Clinical Medicine

Abstract

The aim of this study is to study the onset, duration and characteristics of sensory and motor blockade produced by combination of Midazolam and bupivacaine. All patients received inj. Glycopyrrolate 0.2 mg intramuscularly half an hour before the procedure. No narcotics, benzodiazepines or antiemetics were given. Preoperatively patients underwent a careful and detailed examination. On the operation table and baseline data were entered in the proforma.
Result: Onset of sensory blockade was in the range of 121-180 seconds in majority of patients (n=16, 53.3%) in group I and (n=19, 63.33%) in group II. The difference in mean onset of analgesia among both the groups was statistically insignificant (P>0.05), indicating that addition of Midazolam had not shortened the onset of sensory blockade. Onset of motor blockade was in the range of 241-300 seconds in majority of patients in both groups (n=17, 56.67%) in group I and (n=18, 60%) in group II. The difference in mean onset of motor blockade among both the groups was insignificant statistically (P>0.05) indicating that addition of Midazolam had not shortened the onset of motor blockade.
Conclusion: The two groups did not differ significantly as regards to duration of surgery, time of onset of analgesia, onset of motor blockade, degree of motor blockade, efficacy of analgesia intraoperatively.  A detailed preoperative assessment and routine investigations were done in all patients.  Patients with absolute contraindications for subarachnoid block and those who are taking pain killers, benzodiazepine, MAO inhibitors and tricyclic antidepressants were excluded from the study.  Intrathecal Midazolam with Bupivacaine 0.5% (heavy) produces excellent surgical analgesia and an extended analgesic in postoperative period.