European Journal of Molecular & Clinical Medicine

Abstract

The world's diabetes epicentre is in India. With over 62 million [1] people in India already living with diabetes, the disease is quickly assuming the position of a possible epidemic. The majority of diabetics remain undiagnosed, and even those who are are not getting the right care. Diabetes patients are more likely to experience major complications like retinopathy, cardiovascular illnesses, nephropathy, and neuropathy. One of the most prevalent consequences of diabetes is diabetic neuropathy. However, it is the least researched and its pathophysiology is poorly understood. A major factor in diabetes-related mortality and morbidity is diabetic nephropathy. It has been demonstrated that the early glomerular disease marker microalbuminuria can predict injury to the glomerulus in diabetic nephropathy at a early stage[2]. Cardiac Autonomic Neuropathy (CAN) has been shown to produce cardiac dysfunction in patients with diabetes without coronary artery disease, which raises the risk of sudden unexpected cardiac death [3,4]. It is discovered that a prolonged QTc interval is a particular indication for CAN. QTc was discovered to be an independent predictor for all cardiovascular death in type 2 diabetes. The delirious consequences of CAN might be lessened with early identification and treatment therapies such physical activity, weight loss, certain anti-hypertensive agents, and beta blockade [5]. Microalbuminuria has been linked to QTc interval abnormalities in type 1 diabetics, demonstrating the connection between diabetic nephropathy and cardiac autonomic neuropathy [6]. However, there are not many of these findings for type 2 diabetes. This study's objective is to assess CAN, which can manifest as prolonged QTc, and to investigate if it is associated with microalbuminuria in patients with type 2 diabetic mellitus, as well as to link it with the severity and the overall duration of diabetes.