Comparative study of intranasal steroids sprays alone v/s intranasal steroids with intranasal antihistamines sprays in patients with allergic rhinitis
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 2, Pages 1147-1152
Abstract
Allergic rhinitis, is one of the most common respiratory problems encountered in the clinical practice. The treatment includes combination of allergen avoidance and pharmacotherapy i.e, antihistaminics, corticosteroids and mast cell stabilizers. Present study was aimed to compare intranasal steroids sprays alone v/s intranasal steroids with intranasal antihistamines sprays in patients with allergic rhinitis.Material and Methods: Present study was conducted in patients from 18-45 years of age group, either gender, attending the ENT outpatient clinic, clinically diagnosed with allergic rhinitis. The patient was examined with the assessment scales for nasal congestion and obstruction using the Nasal obstruction Symptom Evaluation (NOSE) scale. 80 patients by computer generated chits randomly allocated to Group S (50 mcg of fluticasone propionate in each spray) and Group SA (Azelastine Hydrochloride 140 mcg, Fluticasone Propionate 50 mcg in each nasal spray). Results: Age and gender distribution was comparable among both groups and difference was not significant statistically. Group S had baseline NOSE score as 80.79 ± 12.22 and at 6 weeks score was 81.88 ± 10.49 and difference was statistically significant (p <0.001). Group SA had baseline NOSE score as 81.88 ± 10.49 and at 6 weeks score was 28.29 ± 8.21 and difference was statistically significant (p <0.001). At baseline NOSE score in group S was 80.79 ± 12.22 while in group SA was 81.88 ± 10.49, difference was not significant statistically (p - 0.078). After 6 weeks, NOSE score in group S was 53.32 ± 9.33 while in group SA was 28.29 ± 8.21, difference was statistically significant (p - 0.023). Conclusion: Combination of intranasal steroids with intranasal antihistamines sprays has significant reduction of symptoms when compared to intranasal steroids spray alone in the management of allergic rhinitis.
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