Salivary Cortisol And Dehydroepiandrosterone In Patients With Recurrent Aphthous Stomatitis
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 1, Pages 5059-5063
Abstract
Background: Recurrent aphthous stomatitis (RAS) is defined as a chronic inflammatory disease characterized by recurrent bouts of one or several shallow, rounded or ovoid, painful ulcers of oral mucosa that recur at intervals of a few days or up to 2–3 months and is of unknown etiology. The present study was conducted to assess salivary cortisol and dehydroepiandrosterone level in patients with recurrent aphthous stomatitis.Materials & Methods: 60 patients of recurrent aphthous stomatitis of both genderswere divided into 2 groups. Group I comprised of patients with recurrent aphthous stomatitis and group II comprised of healthy control. 2 mL of unstimulated whole saliva was collected and salivary cortisol and DHEA levels were measured using ELISA kit.
Results: Group I had 25 males and 35 females and group II had 30 males and 30 females. 48 patients in group I and 22 in group II had salivary cortisol level >3 ng/ml and 12 in group I and 38 in group II had between 1.2–3 ng/mL. The difference was significant (P< 0.05).DHEA levels 48–61 pg/ml was seen in 30 patients in Group I and 7 in group II, <48 pg/ml was seen in 20 in group I and 48 in group II, >61 pg/ml was seen in 10 in group I and 4 in group II. The difference was significant (P< 0.05).
Conclusion: Recurrent aphthous stomatitis patients exhibited higher mean salivary cortisol and dehydroepiandrosterone level compared to the healthy subjects.
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