A Hospital Based Prospective Study to Assess the Serum Albumin Level as a Prognostic Indicator of Acute Ischemic Stroke Using Modified Rankin Scale (MRS) at 3 Months Follow Up of Patients Admitted in General Medicine Ward at Tertiary Care Center
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 8, Pages 1917-1923
Abstract
Background: Serum albumin acts as an independent predictor of mortality in various clinical settings. Serum albumin level at admission was found to be an independent prognostic factor for ischemic stroke outcome in studies done in western population. Some of the studies have shown that albumin transfusion is capable of minimizing volume of infarction and cerebral edema. Hence through this study, the goal is to understand the association between serum albumin on admission and the functional status at 3 months. It also aims to find the other indicators that influence the outcome after ischemic stroke.Materials & Methods: A hospital based prospective study done on 50 patients who got admitted in medical wards of our hospital with first instance of ischemic stroke within the first 72 hours of onset of symptoms. Patients were followed up, and after 90 days following the onset of stroke, were evaluated either in person or over the phone using the Modified Ranking scale to assess their functional status. Statistical analysis was carried out to establish whether a statistically significant association exists between serum albumin level on admission and the stroke severity, as well as the functional outcome at the end of 90 days.
Results: Majority of patients were in the 50-60 years age group with a mean age of 56.8±10.24 years. Among the study population, 30 were males and 20 were females. Hypertension (60%) was found to be the most frequently associated comorbid condition. Patients with low serum albumin level at admission time were directly proportional to severity of stroke at presentation and poor clinical outcome. The patients with poor outcome had significantly more severe neurological deficit on admission measured on Scandinavian Stroke Scale.
Conclusion: We concluded that serum albumin level was inversely associated with severity of stroke at onset and thereafter in outcome on follow up, studies involving large number of patients will throw more light in future in this regard.
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