Clinico-Histological Correlation in Leprosy: A Hospital Based Cross Sectional Study in Tertiary Care Center
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 2, Pages 1360-1363
Abstract
Background: Hansen's disease (leprosy) is a chronic infectious Granulomatous disease mainly affecting skin and peripheral nerves. There are varied clinical presentation & histopathological findings in leprosy which depends on the immunological status of the individual.Aim: The aim of the present study is to determine the clinico-histopathological correlation of all suspected cases of leprosy using Ridly-Jopling system.
Materials & Methods: This is a hospital based cross sectional study done during the period of 1 year from July 2021 to June 2022.Skin biopsy samples received from clinically suspected leprosy patients were stained with H& E stain followed by fite-faraco stain for evaluation of lepra bacilli.
Results: Among the 58 clinically suspected cases of Hansen’s disease, 48 cases shows evidence of leprosy in histopathological examination with a clinico – histopathological correlation rate of 83%. On histopathological examination majority of cases were of Borderline tuberculoid (32%) followed by Lepromatous leprosy (14%). Borderline borderline (BB) gives maximum clinico-histopathological correlation (92%) and Borderline Lepromatous (BL) shows minimum clinico-histopathological correlation.
Conclusion: For accurate classification of disease, correlation between clinical, histopathological and microbiological findings is very crucial. Early clinical diagnosis is cornerstone for Leprosy eradication program. Therefore, all clinically suspicious cases must be followed by histopathological examination of the skin biopsy samples.
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