A Study to Compare the Adjuvant Effects of Clonidine and Dexmedetomidine Given Intrathecally Along with Isobaric Ropivacaine in Lower Limb Surgeries
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 2, Pages 1370-1377
AbstractIntroduction: Spinal anesthesia has been the choice of anesthesia for infraumblical surgeries. Aim: to evaluate the efficacy of adding clonidine (30µg) or dexmedetomidine (5µg) to 0.75% isobaric ropivacaine for administration of subarachnoid lumbar block in lower limb surgical procedures.
Methods: The Hospital based comparative, randomized, double blind, study was done on 120 patients (ASA grade 1-2) undergoing lower limb surgeries at S.M.S. Medical College and attached group of hospitals, Jaipur, after taking permission from the institutional ethical committee and review board. 120 patients were randomized into three groups of 40 each by sealed envelope method as follow: GROUP RS (0.75% Ropivacaine + 0.5 ml Isotonic saline), GROUP RC (0.75% Ropivacaine + 30µg Clonidine), GROUP RD (0.75% Ropivacaine + 5µg Dexmedetomidine).
Results: The mean time taken to achieve maximum sensory level was 18.40 minutes, 11.70mins and 18.80mins in groups RS, RC and RD, respectively (p<0.05). Mean time taken for sensory block to regress to L1 sensory level was 227.50minutes, 202.30minutes and 159.40minutes in groups RC, RD and RS, respectively(p<0.05). The time between the administration of subarachnoid block and request for rescue analgesic was 193.10 minutes, 347.60 minutes and 381.30 minutes in groups RS, RC and RD, respectively (p<0.05).
Conclusion: We conclude that both drugs, Clonidine and dexmedetomidine can be safely added as adjuvant to intrathecal Ropivacaine for lower limb surgeries, in view of similar sensory and motor block characteristics.
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