Evaluating a herbal formulation for particulate matter induced lung tissue degeneration in wistar rat
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 2, Pages 1472-1477
AbstractParticulate Matter (PM) is the biggest challenge for human health as the lungs shows its deleterious impacts even in early pathogenesis. It is imperative to treat the lung tissues with effective and with minimum side effects of the medicine. This study is carried out to evaluate a herbal formulation which included eight plant samples ‘Angelica archangelica (leaf), Dioscorea bulbifera (Root), Fagopyrum dibotrys (Root), Myrtus communis Linn (Leaf), Nasturtum offcinalea (whole Plant), Perilla frutescens (Leaf and Seed), Catharanthus roseus (Whole Plant) and Solanum xanthocarpum (Root). The therapeutic actions were observed against particulate matter concentrations (artificially generated PM exposure) induced lungs tissue degeneration at various dose 100, 200 and 400 mg/kilogram in wistar albino rats for 30 days. Blood sample collected terminally on 30th day has been gone through the hematology test. All surviving animals have been euthanized by high dose of anaesthetics and subjected to a lung necropsy examination at the end of the treatment period Differential cell count in blood have been analysed. As well as in Bronchoalveolar lavage fluid (BALF) also. That has been reduced progressively in all test groups (<0.05, <0.01, <0.001). Histopathology of the lungs reflected inflammatory changes, deform alveolar space, edema and condense of the intra-bronchial wall. In the induced control group and in the treatment group @ doses of 100, 200, and 400 mg/kilogram progressive reduced inflammation alveolar space, and edema. The results showed that the formulation was found therapeutic active against degenerated lung tissue induced by particulate matter in wistar albino rats most effective at a dose of 400 mg/kilogram during 30 days.
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