European Journal of Molecular & Clinical Medicine

Abstract

Aim: We investigated whether FAR had a potential value in evaluating the prognosis of patients with non-metastatic kidney cancer or not.
Methods: The present study was conducted in the department of Urology, Rajendra Institute of medical sciences (RIMS), Ranchi, Jharkhand, India and 50 patients with renal cancer who underwent radical nephrectomy were included in the study.
Results: Of the 50 patients included in the study, 36 (72%) were male and 14 (28%) were female. Of the 50 individuals in our control group, 44 (88%) were male and 6 (12%) were female. The mean age in the patient group was 58.86 (min 34-max 82) and the mean age in the control group was 59.05 (min 32-max 81). There were 43 (86%) patients with grade 1–2 and 7 (14%) patients with grade 3–4 according to Furhman Grade (FG). The distribution by tumor size was similar to the distribution set by FG. According to TNM staging, the number of patients with T1-2 was 43 (86%) and the number of patients with T3-4 was 7 (14%). Median score (min–max) NLR, PLR, HRR, LMR, SLL and FAR in all patient groups were 6.10 (1.17–25.37), 165.0650 (41.30–708.33), 0.9450 (0.44–1.38), 2.4100(0.42–32.87), 1,271,030(102,030–7,203,240) and 0.08000(0.007/0.286) respectively. In the control group, the Median score (min–max) of NLR, PLR, HRR, LMR, SLL and FAR were 1.4500 (0.34–4.69), 93.6250 (67.00–270.23), 1.0250 (0.57–1.35), 2.3000 (1.00–8.09), 505,975.00 (234,546– 1,428,000) and 0.05450 (0.010– 0.117) respectively.
Conclusion: Recently, the prognostic significance of FAR in various cancers has been investigated. In non-metastatic RCC patients, there is a need for indices which have prognostic importance to determine a cut-off during follow-up; to better categorize patients according to grade and tumor size; to reach early treatment and not to impair patients’ quality of life.