European Journal of Molecular & Clinical Medicine

Abstract

The aim of this study is to evaluate and compare the side effects and complication associated with Bupivacaine alone and Bupivacaine + clonidine. All patients received injection rantidine 50mg IV and injection ondansetron 4mg IV and injection GPL 0.2mg IM half an hour before the procedure. After securing a suitable peripheral vein, all patients were administered 500ml of lactate ringers solution.
Result: Onset of sensory blockade was in the range of 121-180 seconds in majority of patients (n=36, 60%) in group I and (n=40, 66.67%) in group II. The difference in mean onset of analgesia among both the groups was statistically insignificant (P>0.05), indicating that addition of clonidine had not shortened the onset of sensory blockade.The difference in mean onset of motor blockade among both the groups was insignificant statistically (P>0.05) indicating that addition of clonidine had not shortened the onset of motor blockade.
Conclusion: Intrathecal clonidine with bupivacaine 0.5% heavy produces excellent surgical analgesia and an extended analgesia in postoperative period. Clonidine treated patients were sedated and comfortable throughout the surgical procedure, thus avoidance of any other medication.