European Journal of Molecular & Clinical Medicine

Abstract

Diabetics are more prone to have liver fibrosis and hence the study was conducted to find any linear correlation between Diabetes Mellitus and liver fibrosis.
MATERIALS AND METHODS: A observational study with 100 diabetic patients was done.  Detailed history was taken and examination done, patients were then subjected to various blood investigation and USG abdomen, after clearance from institutional scientific committee and after taking informed consent during the period of May 2022 to December 2022, in the Department of General Medicine, Index Medical College Hospital & Research Centre, Indore.
AIMS & OBJECTIVES: To establish the correlation of HBA1C with NAFLD in Type 2 DM.
RESULTS: Mean age group was 45 years, range 25 to 70 years. Out of 100 diabetic patients, 54% patients were positive for NAFLD. Out of 36% (65.5%) patients had higher HBA1c levels >8.5%. Thus, NAFLD leads to poor glycaemic controls and vice versa. In the study 62.9% had grade 1 fatty liver., suggesting slow progressive nature of disease. Most of the NAFLD patients (40%) were asymptomatic followed by dyspepsia. Elevated liver enzymes were found in stage 3 and 4 only.
CONCLUSION: The present study concludes that prevalence of NAFLD in DM is 54% being more in males than females with most common age of presentation is 45 to 55. NAFLD is now considered as liver manifestation of metabolic syndrome while NAFLD is associated with and responsible for poor glycaemic control (higher HBA1c levels) in diabetic patients The findings of fatty liver, even in a asymptomatic patients should prompt a thorough research for components of metabolic syndrome, and patients should advised regarding CVD risks, weight loss, smoking cessation, dietary modification, exercises and pharmacological therapies.