Comparative study of intra-articular hyaluronic acid (HA) injection versus platelet rich plasma (PRP) in early knee osteoarthritis
European Journal of Molecular & Clinical Medicine,
2022, Volume 9, Issue 9, Pages 447-452
Abstract
The purpose of the present research was to explore this biologic approach to treat OA, analysing and comparing results of hyaluronic acid (HA) versus platelet-rich plasma (PRP).Methodology: A prospective study with randomised selection of 47 ( 80 knees) patients for the assessment of outcome of treatment of early Osteoarthrosis of knee with intra-articular infiltration of platelet rich plasma (PRP) versus hyaluronic acid (HA) was carried out in the department of orthopaedics at Jawaharlal Nehru Medical College & Acharya Vinoba Bhave Rural Hospital, Sawangi (M), Wardha from July 2012 to April 2014. The patients were grouped into two categories- where 40 knees were injected with intra-articular HA injections and rest was injected with PRP injections. The mean was compared using paired t- test or independent t- test depending on the distribution of samples. The proportions were analysed using Binominal and Chi Square Test.
Results: At 3 months there was significant reduction in VAS and WOMAC scores in both the groups as compared to baseline. At 6 months, the subjects treated with PRP showed a continuous improvement, whereas the subjects treated with HA showed a sharp worsening for both the scores. Although the mean VAS score was 3.50 in the PRP group (SD= 0.847), it was 4.73 in the HA group (SD= 1.219) whereas mean WOMAC score was 37.25 in the PRP group (SD= 5.54), it was 61.98 in the HA group (SD= 4.85).
Conclusion: Treatment with PRP show significantly better outcome compared with HA treatment.
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