Morphological Variations of Human Placenta in Pre-Eclampsia Pregnancy and to Compare the Same with The Uncomplicated or Normal Pregnancy
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 3, Pages 1147-1153
Abstract
Placental insufficiency is a concern in pregnancy brought on by preeclampsia. There is an increase in maternal and fetal mortality as a result. The aim of the study was to study the morphological variations of human placenta in complicated pregnancy and to compare the same with the uncomplicated or normal pregnancy. Materials & Methods: This research makes use of an observational methodology. After obtaining permission from Institutional Ethics Committee studied at the Department of Anatomy at Indore Medical College & Hospital, Indore. There was a total of 220 human placentas used in this study; 110 were from healthy pregnancies serving as controls, and the remaining 110 were from pregnancies complicated by preeclampsia. The morphology of every sample was analyzed. Results: Variation in placental shape was observed, with both groups producing organs with extra lobes. Significant decreases (p < 0.001) were seen in pre-eclampsia for both placental shape, thickness and maternal surface cotyledons. While pre-eclampsia group did have a thinner placenta, the difference was not statistically significant. The cotyledon count in pre-eclampsia group was drastically higher than in uncomplicated group. (p < 0.05). Conclusion: In this investigation, we found that preeclamptic placentae exhibit distinctive morphological alterations. Placental insufficiency, a condition associated with preeclampsia, appears to be the cause of these alterations. However, more extensive placental research using histological and morphometric methods with bigger sample sizes are needed before any conclusion can be drawn
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