European Journal of Molecular & Clinical Medicine

Abstract

To study the correlation of venous blood lactate level and 6 minute walk test in stable COPD
Patients in tertiary health care centre
Materials & methods: Study was conducted on 50 patients from the Department of Respiratory
Medicine at Index Medical College, Research centre and Hospital, Indore and all the tests was
perform with due permission from the Institutional Ethical Committee and informed consent from the
subjects or their legal relatives. Subjects was included on the basis of their diagnosis of COPD as per
GOLD guidelines & laboratory test of venous blood lactate level.
Result: Fifty participants were recruited and 74% of them were male. The median age of all the
participants was 60.48 years.Based on the Severity classification, 12(24%) of them were mild,
21(42%) moderate, 7(14%) severe and 10(20%) very severe.The participants were under regular
treatment. The median of 6MWT was 280.00 m (IQR 67-53.25, 375–205 m). For Normal Lactic acid
the Mean 6MWT was 336.75 mtrs for 12 samples of Group A of COPD Severity Group, 20 of Group
B, 4 of Group C & 1 of Group D. For Abnormal Lactic acid the Mean 6MWT was 171.92 mtrs for 0
samples of Group A of COPD Severity Group, 1 of Group B, 3 of Group C & 9 of Group D.
Conclusion: In conclusion, in COPD patients 6MWT is useful test to assess severity of disease. Our
study has shown that 6MWT correlates well with pulmonary function and quality of life in patients
with COPD. 6MWT can be used as a novel index in the evaluation of functional status of COPD.
More importantly, steps might give additional indication in addition to distance traveled about the
risk of lung hyperinflation. Considerably more work will be needed to investigate the link between
steps and hyperinflation in patients with COPD.