European Journal of Molecular & Clinical Medicine

Abstract

Laryngoscopy and endotracheal intubation result in pressor and sympathoadrenal responses. Certain agents such as Lignocaine and Labetalol can be given to prevent these hemodynamic changes prior to intubation.
Materials and Methods: 60 patients of ASA grade I, scheduled for various surgeries under general anaesthesia were divided into 2 Groups. Patients in Group A were given 2% Inj. Lignocaine hydrochloride (preservative free) intravenously at 1.5mg/kg over 10 seconds, 90 seconds before laryngoscopy. Patients in Group B were administered 0.5 mg/kg Inj. Labetalol IV, 10 minutes before intubation. Laryngoscopy and endotracheal intubation were performed after induction. Heart rate, systolic, diastolic and the mean arterial blood pressure were recorded before induction, after induction, during intubation and at 1, 3 and 5 minutes post intubation.
Results: Heart rate, systolic and diastolic blood pressures and the mean arterial pressures were significantly lower in the Labetalol group when compared to the Lignocaine group, with the mean arterial pressure and the heart rate attaining the basal value in the Labetalol group after 5 minutes of intubation, while it was still higher in the Lignocaine group.
Conclusion: Labetalol is a better drug for the attenuation of the hemodynamic changes that take place during intubation compared to Lignocaine.