European Journal of Molecular & Clinical Medicine

Abstract

Oral cavity in humans act as one of the most frequent areas for the development of overgrowths. These overgrowths can be categorized on the basis of their etiopathogenesis, site, size and their extent.  These enlargements mostly effect a particular region and are localized in nature,  like pyogenic granuloma, irritation fibroma, peripheral ossifying fibroma, peripheral calcifying fibroma. These overgrowths seldom occur in aggressive forms and frequently occur due to chronic irritation or stimuli over the particular area. [1].
Irritation fibromas are basically provoked fibrous connective tissue overgrowths which are benign in nature and appreciated mostly in oral cavity. Particularly, in  “Inflammatory hyperplasic lesion there is an increase in the size of an organ or tissue due to a local response of tissue to injury or an aggravation in the number of constituent cells.” The trauma may occur from vigorous entrenchment of any foreign substance or irritant into the oral tissues [2].
These lesions are most commonly hyperplastic reactions that occur in response to chronic irritation or stimuli. The most familiar location of occurrence include, buccal mucosa, gingiva, tongue and lips but they also have the predilection to occur at other soft tissue locations in the oral cavity [1].
 These overgrowths can occur in both genders and at any age but slightly a higher predilection is seen in middle aged females. Fibromas  mainly develop from the periodontal ligament or from gingival connective tissues. They are defined clinically as slow growing tumors which are well defined, spherical in shape, smooth surface, firm in consistency, have a broad base and may be sessile or pedunculated. Fibromas are generally painless overgrowths and gradually increase in size over the progression of time [3].
The  histopathological diagnosis of fibroma is mandatorily required to demarcate its difference from other clinically identical hyperplastic lesions or neoplasm of the oral cavity.