European Journal of Molecular & Clinical Medicine

Abstract

The onset of action of bupivacaine is between 4 and 6 minutes, and maximum anaesthesia is obtained between 15 to 20 minutes. The duration of anaesthesia varies according to the block; the average duration of peridural block is about 3.5 to 5 hours and for nerve blocks, it is about 5 to 6 hours. The short duration of action of fentanyl is associated with decrease in the concentration of the drug due to its rapid redistribution to inactive sites such as fat and skeletal muscles.86% is protein bound. High volume of distribution of 3 to 6 L/Kg. Context sensitivity half time is 260 minutes after a 4 hour infusion. Patients were prospectively randomized in to two groups with 30 patients in each group. All Patients were kept nil by mouth for overnight before surgery. To ensure that all the patients received the same medications before and during the surgery, a standardized anesthetic protocol and technique were used. In the operating room standard anesthesia monitors were attached to the patient to monitor: Heart rate, ECG, peripheral oxygen saturation, blood pressure. Intravenous access was obtained using a 20G/18G IV cannula. The minute to minute variation of averages of SBP was more pronounced in Group A, whereas the average SBP was more consistent in Group B. The minute to minute variation of averages of HR was very much higher in Group A, than in Group B.
Conventional dose of bupivacaine, low dose bupivacaine along with fentanyl, hemodynamic changes