European Journal of Molecular & Clinical Medicine

Abstract

Liposarcoma are malignant tumour of fatty tissue and are the malignant counterpart to benign lipoma. They are the second most common type of soft tissue sarcoma. There are 3 groups of liposarcoma well-differentiated (WDL) and dedifferentiated liposarcoma (DDL), myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions like dedifferentiated liposarcoma or minimize surgical morbidity in the myxoid/round cell liposarcoma group. Classification based on histological appearance is not always precise, especially because of the partial overlap of histological features of well-differentiated liposarcoma and Pleomorphic liposarcoma that may be better differentiated based on MDM2 expression on Immunohistochemistry. Detection of MDM2 and CDK4 amplification serves to determine the treatment modality. The differential diagnosis between well-differentiated liposarcoma and dedifferentiated liposarcoma from their morphologic counterparts is challenging