European Journal of Molecular & Clinical Medicine

Abstract

To Study the presence of micronucleus in urothelial cells of patients with normal and abnormal cervical visual inspection and to correlate with cytological and histological findings in normal and various intraepithelial lesions of cervix and cervical carcinoma. To assess the role of urothelial MN score in predicting cervical cancer risk.
Materials and Methods: A total of 350 patients with the complaints of post coital bleed, lower abdominal pain, menstrual irregularities who come in gynaecological out patient department of Rajindra Hospital and Medical College, Patiala were included in our study. Patient’s cervix was visually examined, pap smear taken and midstream urine sample collected for MN scoring. Incidence of micronucleus in urothelial cells recorded as micronucleus cells per 1000 cells by 4 cytopathologists.
Results: The mean Urothelial MN score ± Standard deviation was found to be 2.80±1.58 in inflammatory cases,4.55±1.63 in ASCUS cases,5.67±0.58 in ASC- H cases ,5.61±0.50 LSIL cases, 6.09±0.30 in cases of HSIL,6.50±0.53 in invasive carcinoma. A step-wise increase was observed in MN score from inflammatory to IC categories.
Conclusion: Urothelial MN score is a reliable and easy test that can be used along with routine cervical PAP to assess the risk of premalignant  and  malignant transformation in the cervix as a biomarker for predicting the risk of carcinoma.